Hitoshi Okazawa Selected Research

polyglutamine-binding protein 1

11/2021	Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation.
10/2018	The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology.
9/2005	PQBP-1 is expressed predominantly in the central nervous system during development.

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Hitoshi Okazawa Research Topics

Disease

11	Alzheimer Disease (Alzheimer's Disease) 10/2021 - 03/2009
10	Huntington Disease (Huntington's Disease) 04/2021 - 10/2003
9	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2022 - 11/2005
8	Intellectual Disability (Idiocy) 01/2020 - 09/2005
8	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 08/2017 - 05/2002
5	Cognitive Dysfunction 11/2021 - 01/2016
3	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 12/2021 - 01/2018
3	Necrosis 04/2021 - 01/2020
3	Microcephaly 10/2018 - 09/2005
3	X-Linked Mental Retardation (Mental Retardation, X Linked) 04/2014 - 04/2012
2	Inflammation (Inflammations) 11/2021 - 01/2015
1	Pathologic Processes 06/2022
1	Schizophrenia (Dementia Praecox) 01/2022
1	Encephalitis (Encephalitis, Rasmussen) 11/2021
1	Bites and Stings (Sting) 11/2021
1	Carotid Stenosis (Carotid Artery Stenosis) 01/2019
1	Classical Lissencephalies and Subcortical Band Heterotopias 01/2019
1	Lissencephaly 01/2019
1	Frontotemporal Dementia (Semantic Dementia) 01/2018
1	Disease Progression 01/2015
1	Postmortem Changes (Adipocere) 01/2011
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 11/2010
1	Learning Disabilities (Learning Disability) 10/2010
1	Seizures (Absence Seizure) 11/2005

Drug/Important Bio-Agent (IBA)

13	polyglutamineIBA 06/2022 - 05/2002
12	Proteins (Proteins, Gene)FDA Link 06/2022 - 10/2003
8	HMGB1 Protein (HMG1)IBA 12/2021 - 11/2008
5	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 11/2008
4	Ataxin-1IBA 01/2015 - 04/2003
3	polyglutamine-binding protein 1IBA 11/2021 - 09/2005
3	Amyloid (Amyloid Fibrils)IBA 04/2021 - 01/2018
3	PhosphoproteinsIBA 04/2021 - 01/2011
3	Amyloid beta-PeptidesIBA 01/2020 - 07/2015
3	Carrier Proteins (Binding Protein)IBA 01/2020 - 11/2009
2	AntibodiesIBA 01/2022 - 01/2017
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2021
2	Myristoylated Alanine-Rich C Kinase SubstrateIBA 01/2020 - 07/2018
2	Nuclear Proteins (Protein, Nuclear)IBA 01/2015 - 11/2011
2	RNA (Ribonucleic Acid)IBA 01/2013 - 01/2012
2	HMGB ProteinsIBA 01/2012 - 11/2011
2	Mutant Proteins (Protein, Mutant)IBA 01/2012 - 07/2010
2	ProteomeIBA 11/2011 - 01/2011
1	Intrinsically Disordered ProteinsIBA 06/2022
1	AutoantibodiesIBA 01/2022
1	Neural Cell Adhesion Molecules (Neural Cell Adhesion Molecule)IBA 01/2022
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 11/2021
1	InterferonsIBA 11/2021
1	Tamoxifen FDA LinkGeneric 11/2021
1	tau Proteins (tau Protein)IBA 11/2021
1	Complementary DNA (cDNA)IBA 11/2021
1	Serine (L-Serine)FDA Link 01/2020
1	Cadherins (E-Cadherin)IBA 01/2019
1	Cell Cycle ProteinsIBA 10/2018
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2018
1	Phosphotransferases (Kinase)IBA 01/2018
1	ProgranulinsIBA 01/2018
1	Protein AggregatesIBA 01/2017
1	Small Molecule LibrariesIBA 09/2016
1	Histidine (L-Histidine)FDA Link 09/2016
1	Pharmaceutical PreparationsIBA 09/2016
1	Monoclonal AntibodiesIBA 01/2016
1	PhosphopeptidesIBA 01/2015
1	Receptor for Advanced Glycation End ProductsIBA 01/2015
1	Mitochondrial DNA (mtDNA)IBA 01/2015
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2015
1	Eosine Yellowish-(YS) (Eosin)IBA 08/2013
1	Hematoxylin (Haematoxylon)IBA 08/2013
1	Transcription Factors (Transcription Factor)IBA 01/2013
1	Ataxin-7IBA 03/2012
1	TATA-Box Binding Protein (TATA-Binding Protein)IBA 03/2012
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2011
1	Antisense OligonucleotidesIBA 11/2010
1	Vorinostat FDA Link 10/2010
1	Histone Deacetylase InhibitorsIBA 10/2010
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 07/2008
1	Small Interfering RNA (siRNA)IBA 01/2007
1	Kainic Acid (Kainate)IBA 11/2005
1	Cytochromes c (Cytochrome c)IBA 11/2005
1	Caspase 3 (Caspase-3)IBA 11/2005
1	Histone Deacetylases (Histone Deacetylase)IBA 10/2003

Therapy/Procedure

5	Therapeutics 12/2021 - 01/2017
1	Subcutaneous Injections 01/2016